📉 When Collagen Drops… Here’s What Helps

Growth factors, exosomes + more

Hey Purists,

Skincare has entered a totally new era. We’re not just exfoliating and retinol-ing our faces into submission anymore.

We’re talking about cell signaling — ingredients that teach your skin how to repair itself better.

Today I want to break down three topics I keep getting asked about:
👉 growth factors
👉 exosomes
👉 topical estrogen

Inside this issue:

✔️ The Ingredient That “Re-Trains” Your Skin. Why I reach for it when my barrier is freaking out (and what NOT to mix it with)
✔️ Exosomes Explained (Finally). The part no brand talks about… and when they actually make a real difference
✔️ Topical Estrogen. The conversation almost every woman is missing (and the safe way to approach it)
✔️ Repair vs. Aggress. The simple 2-phase protocol I use instead of guessing and overdoing actives
✔️ My Nightly Stack. The exact order I layer these new actives so they work with my skin, not against it
✔️ The Rules I Never Break. Tiny decisions that quietly change everything about age, glow, and resilience

(If you loved our issues on Detox Dilemma, Hormones & Skin, or Why Anti-Aging Is the Wrong Goal, this one connects the dots beautifully.)

Let’s get into the PURE TRUTH.

🌿 Growth Factors — the repair messengers

Growth factors are proteins your body naturally produces that tell skin cells:

“Repair, rebuild collagen, heal stronger.”

🙌 Why I like them

I reach for growth factors when I want my skin to: